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Cerebral ischemic models

Global cerebral ischemia

  • Four vessel occlusion

Focal cerebral ischemia

  • Transient/permanent middle cerebral artery occlusion (filament model)
  • Endothelin-1 model
  • Photothrombotic lesion

Cerebral hemorrhage models

Subarachnoid & cerebral hemorrhage

  • Blood injection

Functional recovery study

  • Modified neurological severity score
  • Limb placing test
  • Single pellet reaching task
  • cylinder test
  • Rotarod
  • Adhesive tape removal
  • Morris water maze

Infarct volume measurement

  • Magnetic resonance imaging (MRI)
  • Tetrazolium chloride (TTC)

Validation data

Click below to see a sample data set

Test-compound administration

Routes

  • Epidural
  • Intrathecal
  • Intracerebroventricular
  • Others: i.v., s.c., p.o., i.p., i.m…

Dose regimen

  • Single, repeated or chronic (osmotic pump)