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Spasticity is a disabling complication of spinal cord injury or stroke. Spasticity is defined as a symptom of the upper motor neuron syndrome characterized by an exaggeration of the stretch reflex secondary to hyperexcitability of spinal reflexes. In this condition, the muscles are stiff or rigid, which interfere with walking, movement or speech.

“Evaluate the efficacy of your neuroprotective or neuro-regenerative therapeutic compounds”


Spinal cord injury (SCI)



Outcome evaluation

Monosynaptic reflex: Rate-Dependent Depression (RDD) of the Hoffmann's reflex (H-reflex)

The H wave amplitude is attenuated by repeated activations at frequencies higher than 0.2 Hz, with a maximum reduction at 5 Hz in intact rats. The RDD is progressively reduced in individuals with SCI, and this effect is a reliable correlate of the development of the spasticity.


Polysynaptic reflex: hindlimb muscle spasms evoked with stimulation of the tibial nerve, in awake chronic adult SCI rat

When the tibial nerve is stimulated in acutely injured rats, a little reflex is evoked in the FDB muscle EMG recordings, regardless of the stimulation current intensity. In contrast, stimulation of the tibial nerve in chronic spinal rats produced more long-lasting muscle contractions. This effect is a reliable correlate of the development of the spasticity.


Validation data

Effective spasticity suppression with a single intravenous administration of baclofen

The mean relative amplitudes of the H-reflex were significantly reduced (Kruskal-Wallis, Dunn's post-test) in baclofen-injected SCI rats (n=10) compared with vehicle-injected SCI rats (n=10). After a single I.V. administration, baclofen has an onset of action of 6 min, a maximum effect of 46 min (P < 0.05 at 1 Hz, P < 0.01 at 2 – 5 Hz) and a duration of action of at least 86 min.




Prochlorperazine Increases KCC2 Function and Reduces Spasticity after Spinal Cord Injury

What clients are saying

"We thank the company NSrepair for their help in surgery and postoperative care"

"The results were obtained at a specialist in vivo pharmacology research organization, NSrepair, in Marseille, France, under the supervision of Dr. Philippe Marino."

Scientific advisor

Doctor Fréderic Brocard - Team Leader, Neuroscience Institute of la Timone (Marseille - France). Frédéric runs a team which explores the plasticity of rhythmic motor networks both during development and in pathological conditions. He is a scientific consultant for NSrepair and reviews our studies.

Test-compound administration


Dose regimen


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Spinal cord injury models