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More than 2.5 million of patients around the world

Depending on their location and severity, Spinal Cord Injury results in paralysis, loss of sensation, respiratory or urogenital disorders, and chronic pain. Patients demonstrate lower rates of school enrollment and economic participation and are two to five times more likely to die prematurely


“Evaluate the efficacy of your neuroprotective or neuro-regenerative therapeutic compounds”

Models

Contusion

Transection


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Functional recovery study

Locomotion, coordination, balance, strength

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Touch sensitivity

Spasticity

Autonomic bladder control

Validation dataset (Published)

A polysialic acid mimetic peptide promotes functional recovery in a mouse model of spinal cord injury


Delivery of PR-21 to the lesion site enhanced motor functions, sensorimotor control and coordination of hindlimbs with forelimbs, and decreased the time of the animals' return to continence when compared to vehicle alone or a control.

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References

Publications

A polysialic acid mimetic peptide (Compound A) promotes functional recovery in a mouse model of spinal cord injury


Polysialylation of the Neural Cell Adhesion Molecule: setting the stage for plasticity across scales of biological organization

What clients are saying

"We thank the company NSrepair for their help in surgery and postoperative care"

Test-compound administration

Routes

Dose regimen


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Spasticity models